• Programmed death ligand PD L expression is a characteristic

  2019-06-05

  

  Programmed death ligand 1 (PD-L1) expression is a characteristic feature of EBV-associated malignancies. Research has shown that an increase of PD-1-expressing intratumoral CD8 T cells predicts a poor prognosis for nasopharyngeal carcinoma. Preliminary data from a phase Ib study, KEYNOTE-028, showed

• The WHO guidance promotes pre exposure prophylaxis for all p

  2019-06-05

  

  The 2016 WHO guidance promotes pre-exposure prophylaxis for all populations with an incidence of HIV above three per 100 person-years. This guidance is, some ways, an indictment on the promotion of condoms in HIV prevention. However, WHO does not retract its message regarding the use of condoms. The

• The work by Fumiaki Imamura

  2019-06-01

  

  The work by Fumiaki Imamura and colleagues in this issue of is a unique attempt to evaluate measures of dietary quality and their trends in most countries worldwide. They used a wide range of data sources, including nationally representative dietary surveys, local surveys, and foods disappearance d

• br At least people were killed and eight

  2019-06-01

  

  At least 69 people were killed and eight others were missing after a landslide in Shenzhen, north of Hong Kong, on Dec 20, 2015. Unlike most landslides triggered by high-intensity rainfall or earthquakes, this online job disaster was man-made and triggered by the collapse of a construction waste

• Close inspection of the tumor matrix on

  2019-06-01

  

  Close inspection of the tumor matrix on the initial and subsequent 5 month radiographs (Fig. 7), shows an atypical appearance for osteoid matrix that serine protease inhibitors may more closely resemble chondroid matrix. The matrix appears to display a linear dense lace-like pattern (Fig. 8). Of th

• Good news from the Americas illuminated the

  2019-06-01

  

  Good news from the Americas illuminated the global health scene in September. As the Ministers of Health from the western hemisphere gathered in Washington, DC, USA, for PAHO\'s 55th Directing Council, a series of announcements confirmed the New World\'s role as a pioneer of sorts in disease prevent

• br Vascular cells and the

  2019-06-01

  

  Vascular cells and the peribiliary vascular plexus The liver is a highly vascularized organ that receives dual blood supplies from the hepatic portal vein (HPV) and hepatic Nutlin-3a (Fig. 1). The HPV delivers approximately 75% of the total blood supply that the liver receives and carries from t

• Since the Food Safety Standards Authority of India has

  2019-05-31

  

  Since 2006, the Food Safety Standards Authority of India has led efforts to promote food safety, tighten food laws, and harmonise these laws with international standards and quality-management systems. These efforts need to be complemented with interventions focused on practices at the household lev

• thymidine phosphorylase The majority of breast malignancies

  2019-05-31

  

  The majority of breast malignancies are hormone responsive, and adjuvant endocrine therapy is used routinely to prevent breast cancer recurrence and death [6,7]. Tamoxifen was the past treatment of choice for endocrine-responsive postmenopausal breast cancer and was found to preserve BMD in postmeno

• Nos anos de alguns setores da Igreja

  2019-05-31

  

  Nos anos de 1970 alguns setores da Igreja católica iniciaram uma nova etapa na ligação da instituição com as elites e a política. Outrora a Igreja era parte integrante desse arranjo, neste período se converteu em contestadora da acumulação financeira, das desigualdades, do latifúndio e da autoridade

• br Discussion br Conflict of interest br Introduction Device

  2019-05-31

  

  Discussion Conflict of interest Introduction Device implantations may be challenging in patients with venous abnormalities. The most common congenital variation, frequently associated with other congenital abnormalities, is a persistent left superior vena cava (PLSVC), and successful atrial

• br Material and methods br Results br Discussion PV isolatio

  2019-05-31

  

  Material and methods Results Discussion PV isolation is currently the cornerstone for treatment of patients with paroxysmal AF [6]. An extended technique is circumferential PV isolation using point-by-point ablation around the PV ostium. However, that is a technically challenging and time-c

• Asimismo el texto convoca a

  2019-05-30

  

  Asimismo, el texto convoca Bafilomycin A1 cuestionar muchos de los mitos sobre la guerra civil en Guatemala. No fue durante los años setenta que los revolucionarios guatemaltecos volcaron su mirada sobre el componente indígena como parte de las fuerzas insurgentes, tampoco fue en los ochenta que el

• br Identidade negra e quilombola O uso da

  2019-05-30

  

  Identidade negra e quilombola O uso da expressão “remanescentes” para classificar os agrupamentos negros, enquanto unidades que guardam correspondência histórica com os quilombos, motivou reflexões sobre seu significado. Adotamos o entendimento de que ao contrário do sentido de sobra ao qual pode

• br China experienced unprecedented heavy smog pollution in t

  2019-05-30

  

  China experienced unprecedented heavy smog pollution in the winter of 2016–17. Northern Chinese areas surrounding Beijing suffered most seriously. At the beginning of 2017, the Ministry of Science and Technology of China started to implement a special focus research programme on the causes and con

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