• br Discussion Herein we demonstrate that mice deficient

  2024-06-22

  

  Discussion Herein, we demonstrate that mice deficient in L-12/15 LO are more sensitive to 3-NP-induced toxicity although a substantial individual variability in striatal lesion size in response to 3-NP in both genotypes was observed. This variability is not atypical; several studies demonstrate s

• The most likely explanation for the

  2024-06-22

  

  The most likely explanation for the species differences in aromatase distribution and the unique dna-pkcs distribution in humans is the unique location, size and highly elaborate organization of the human aromatase gene (e.g. Bulun et al., 2003). The human Cyp19 is a large gene located on chromosome

• br Conflicts of interest br Introduction Arginase catalyzes

  2024-06-22

  

  Conflicts of interest Introduction Arginase catalyzes the reaction in which l-arginine is converted to l-ornithine and urea. In humans, two arginase isoenzymes have been identified, arginase 1 and arginase 2, that differ in cellular location and tissue distribution [1]. Both arginase enzymes a

• Weak and transient interactions of HMGB proteins in such

  2024-06-22

  

  Weak and transient interactions of HMGB proteins in such hit-and-run mechanisms are understandable given that “fluorescence loss in photobleaching” (FLIP) experiments employing GFP-labeled HMGBs have shown that in living cells they are the most mobile of all nuclear proteins [144]. The entire pool o

• Since artemisinin shows low solubility and poor oral bioavai

  2024-06-22

  

  Since artemisinin shows low solubility and poor oral bioavailability [8], [9], derivatizations of artemisinin were carried out and yielded different semisynthetic antimalarial drugs such as artemether and sodium artesunate. Artemether (decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano [4.3-

• br Material and methods br Results br

  2024-06-22

  

  Material and methods Results Discussion Aminopeptidase N is a transmembrane protease present in a wide variety of human tissues and cell types (endothelial, epithelial, fibroblast, leukocyte). APN expression is dysregulated in inflammatory diseases as well as in solid and hematologic tumors

• br Materials and methods br Results br Discussion

  2024-06-22

  

  Materials and methods Results Discussion Competing financial interests Acknowledgements The work was partially supported by grants from the National Natural Science Foundation of China (Grant no. 31530053 and 31401424) and National Science and Technology Support Plan (Grant no. 2013BA

• br Methods br Results br

  2024-06-22

  

  Methods Results Discussion Chronic stress renders individuals vulnerable to diseases, and this effect might be, at least partially, mediated by stress hormone-induced immunosuppression. Therefore, investigating the effects of catecholamines on immune A 779 is of high relevance. We hypothesi

• br Adenosine and tumor microenvironment

  2024-06-22

  

  Adenosine and tumor microenvironment In the majority of carcinogenic processes a proinflammatory state is generated [36], [37]. In addition, a tumor hypoxic environment is generally due to inadequate perfusion of oxygen to the tumor [38]. Immunomodulators are molecules that regulate the immune r

• Plant material and growth conditions Arabidopsis thaliana

  2024-06-21

  

  Plant material and growth conditions. Arabidopsis thaliana ecotype Columbia was grown on a mixture of soil, vermiculite, and perlite (4:2:1) with a 16h light/8h dark W123 synthesis in a temperature-controlled growth room (22°C), unless indicated otherwise. Molecular cloning and plant transformation

• The zebrafish Danio rerio is a

  2024-06-21

  

  The zebrafish (Danio rerio) is a popular model organism for virtually any biological function of vertebrates, and has, therefore, received a wide distribution in particular in developmental biology and toxicology (Strähle et al., 2012). With respect to AChE, the zebrafish has, e.g., been identified

• Given the profound expression of HT A and

  2024-06-21

  

  Given the profound atp citrate lyase of 5-HT1A and 5-HT2A in the hippocampal CA1 region, and their potential to complex with mGluRs, the objective of this study was to examine if sleep deprivation alters the expression of 5-HT1A and 5-HT2A receptors and determine whether potential changes are reve

• Recent studies have indicated that V ATPase activity

  2024-06-21

  

  Recent studies have indicated that V-ATPase activity negatively regulates vacuolar fusion in vivo[17]. Since we have demonstrated that the pah1Δ Phosphatase Inhibitor Cocktail 3 (100X in DMSO) have a more acidic vacuolar pH than the WT cells, and the genes involved in the pump activity are upregulat

• T7 High Yield Cy3 RNA The importance of the ATM Tel

  2024-06-21

  

  The importance of the ATM/Tel1 to ATR/Mec1 switch in the response to DSBs remains to be determined. Noteworthy, resection-defective S. cerevisiae cells, such as sae2Δ, exo1Δ, fun30Δ or sgs1Δ mutants, fail to turn off the checkpoint in response to an unrepaired DSB [56], [127], [128]. Moreover, the s

• br Results Four HT esters butyrate

  2024-06-21

  

  Results Four HT esters (butyrate, caprylate, laurate and stearate esters) were chosen as representative compounds of increasing lipophilicity (Fig. 1). We will refer to them as C4HT, C8HT, C12HT and C18HT, respectively. They have been synthesized, purified and characterized according to our previ

15798 records 90/1054 page Previous Next First page 上5页 8687888990 下5页 Last page