• HCV NS A inhibits induction of the type I interferon

  2021-11-18

  

  HCV NS3/4A inhibits induction of the type I interferon response by cleaving MAVS from the mitochondrial surface (Li et al., 2005b). MAVS is cleaved at cysteine 508, and L-α-Aminoadipic Acid of cysteine 508 to arginine (C508R) abrogates cleavage (Li et al., 2005b). GBV-B and the related canine hepat

• Recent studies on detailed biochemical and structural

  2021-11-18

  

  Recent studies on detailed biochemical and structural characterization of plant GSNOR CH 223191 confirmed their similarities to mammalian homologues [16], [17], [18], [19]. Compared to human GSNOR, plant GSNORs exhibit differences in the composition of the anion-binding pocket, which negatively inf

• Human GPR hGPR was originally isolated in

  2021-11-18

  

  Human GPR55 (hGPR55) was originally isolated in 1999 as an orphan GPCR with high levels of expression in human striatum (Sawzdargo et al., 1999) (Genbank accession # NM_005683.3). hGPR55 was mapped to human chromosome 2q37, and in the human CNS it is predominantly localized to the caudate, putamen,

• Gp induces cell death by apoptotic mechanisms and

  2021-11-17

  

  Gp120 induces cell death by apoptotic mechanisms and increases intracellular Ca, and activates messengers related to cell death. Intracellular mechanisms of neuronal damage are mainly a consequence of the activation of the N-methyl-d-aspartate receptor (NMDAR) [2], [5], which induces excitotoxicity

• br Concluding Remarks br Outstanding Questions br Acknowledg

  2021-11-17

  

  Concluding Remarks Outstanding Questions Acknowledgments Research on DNA glycosylases in our laboratory is supported by the National Science Foundation (MCB-1517695). A.A.R. and N.P.B. are supported by the National Science Foundation Graduate Research Fellowship Program (DGE-1445197). In

• The CO chemosensitivity of the LH PFA

  2021-11-17

  

  The CO2 chemosensitivity of the LH/PFA has been shown to be dependent on sleep-wake states (B.S. Deng et al., 2007; Dias et al., 2010, 2009; Li et al., 2013). In this context, it was demonstrated that focal acidification of the LH/PFA, by microdialysis of acidic artificial cerebrospinal fluid (aCSF)

• Previous reports have showed that the expression

  2021-11-17

  

  Previous reports have showed that the expression and localization of GLUT8 in mouse (Gómez et al., 2006; Kim and Moley, 2007), rat (Ibberson et al., 2002) and human (Schürmann et al., 2002). In this study, GLUT8 protein mainly localized in the spermatocytes, elongated and round spermatids in the adu

• We speculated modulation of redox

  2021-11-17

  

  We speculated modulation of redox balance in brain, by activation of GIP receptor pathway. QA is known to mediate production of ROS, lipid peroxidation by its interactions with Fe2+ and formation of QA-Fe2+ complex (Braidy et al., 2010, Rios and Santamaria, 1991, Stipek et al., 1997). QA induces NOS

• br Materials and methods br Results Bgal from

  2021-11-17

  

  Materials and methods Results Bgal from Alteromonas sp. ML117 had an open reading frame of 3126 bp encoding 1042 amino CH5138303 residues with a predicted mass of 120 kDa and a theoretical pI (isoelectric point) of 5.44. The recombinant Bgal contained a His tag, as well as other additional am

• Further our data demonstrate a role

  2021-11-17

  

  Further, our data demonstrate a role for mitochondrial AIF in oxidative cell death induced by RSL3. We found that AIF knockdown using siRNA completely protected the SGC707 against RSL3 induced oxidative stress. Similar to other pathways of caspase-independent programmed cell death, mitochondrial da

• Following these discoveries the term ferroptosis

  2021-11-17

  

  Following these discoveries, the term ferroptosis was coined in 2012 [25], to describe this iron-dependent, non-apoptotic form cell death induced by erastin and RSL3. This discovery was accompanied by the development of the first small molecule ferroptosis inhibitor, termed ferrostatin-1, and the de

• To validate that our natural experiment operates primarily t

  2021-11-17

  

  To validate that our natural experiment operates primarily through a large negative shock to the risk-taking incentives provided by option compensation measured by vega, we do two sets of tests. First, we confirm a significant drop in vega after the adoption of FAS 123R for treated firms relative to

• Neither E nor Z FPP synthase catalyzed the

  2021-11-17

  

  Neither E- nor Z-FPP synthase catalyzed the reaction between 8-THPOGPP and IPP. However, a mutant E-FPP synthase (Y81S) produced 12-THPOFPP from the substrates 8-THPOGPP and IPP, and wild-type E-FPP synthase catalyzed the reaction betweeen 8-AcOGPP and IPP producing 12-AcOFPP. Mutant E-FPP synthase

• br Materials and methods br Results and discussion

  2021-11-17

  

  Materials and methods Results and discussion To analyze the dependence of lysosomal exocytosis on Cu we exposed HeLa pdgfr to fresh buffer containing normal levels of free Ca (1mM) and measured β-hex levels in the extracellular medium, followed by measuring β-hex content in the total cellular

• SCH is a H R

  2021-11-17

  

  SCH-497079 is a H3R receptor antagonist introduced by Schering-Plough, without any publicized pharmacological and structural information. A Phase II clinical trial assessment of SCH-497079 on weight has been completed in a multicenter, randomized, parallel-group and placebo-controlled study in obese

15797 records 523/1054 page Previous Next First page 上5页 521522523524525 下5页 Last page