• The nuclear repressor BACH is known to control

  2022-06-13

  

  The nuclear repressor BACH1 is known to control HO-1 expression together with the transcriptional activator NRF2. The results of our study show that HO-1 gene expression in LPS-stimulated macrophages is primarily regulated via BACH1. This idea is supported by a series of experimental evidence demons

• br Author Contributions br Acknowledgments We

  2022-06-13

  

  Author Contributions Acknowledgments We thank Hiroyuki Miyoshi, Makoto Nakanishi, Yoshikazu Johmura, Yuki Okada, Yoshinori Makino, Takashi Sutani, and Katsuhiko Shirahige for kindly providing materials and technical information, Shiho Takahashi-Kariyazono for technical advice, and all members

• Considering its role in regulating cytoskeletal dynamics

  2022-06-13

  

  Considering its role in regulating cytoskeletal dynamics, the Rho kinase effector ROCK has been particularly implicated in tumor metastasis. The ROCK inhibitors Y27632 and fasudil have been extensively studied in cancer and beneficial effects have been observed in many types of cancers (Kale et al.,

• br Cholecystokinin CCK CCK is

  2022-06-13

  

  Cholecystokinin (CCK) CCK is secreted by enteroendocrine I-cells of the duodenum and jejunum in response to amino acids and lipids [14]. There are two forms of the CCK receptor, CCK1 which is expressed on pancreatic α- and β-cells while CCK2 is located on somatostatin-secreting δ-cells [8]. CCK r

• To combat the detrimental effects

  2022-06-13

  

  To combat the detrimental effects of neuropathological conditions, additional therapeutic interventions that either dampen chronic neuroinflammation or attenuate reductions in hippocampal neurogenesis are critically needed. The cannabinoid system has already been shown to rescue impaired neurogenesi

• nf-κb inhibitor We did however observe that niacin treatment

  2022-06-13

  

  We did, however, observe that niacin treatment impaired DC accumulation in skin-draining lymph nodes (Fig. 2). Attenuated adaptive immunity, assessed using a contact hypersensitivity assay (Fig. 4), was observed, as would be expected from impaired DC accumulation in lymph nodes, though other mechani

• The activation of the ERK pathway may participate in

  2022-06-13

  

  The activation of the ERK pathway may participate in the sensitization of primary afferents in pain transmission (Ji et al., 2009, Lai et al., 2011); the blockade of ERK activation in the DRG can decrease mechanical and heat hypersensitivity in inflammatory pain. IL-10 can inhibit phosphorylation of

• SGCs tightly ensheath the soma of DRG neurons Costa and

  2022-06-13

  

  SGCs tightly ensheath the soma of DRG neurons (Costa and Moreira, 2015, Hanani, 2005, Takeda et al., 2009). Intimate associations between SGCs and neurons facilitate bidirectional regulation of SGC function and neuronal excitability. After nerve injury, neuronal hyperexcitability can result in SGC a

• The HH Gli pathway has been demonstrated to play an

  2022-06-13

  

  The HH-Gli pathway has been demonstrated to play an extensive role in skeletal development. India Hedgehog, derived from hypertrophic chondrocytes, and Parathyroid Hormone-like related Protein (PTHrP), derived from peri-articular chondrocytes, form a negative feedback loop to inhibit chondrocyte hyp

• br Acknowledgments The research leading to

  2022-06-10

  

  Acknowledgments The research leading to these results was funded by European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement No. 222719 – LIFECYCLE and by the Foundation for Science and Technology of Portugal (FCT), through projects PTDC/MAR-BIO/3890/2012 and PEst-C/

• In addition at the spinal level

  2022-06-10

  

  In addition, at the spinal level, results from colocalization experiments demonstrate that GABA-C receptors are present in the substantia gelatinosa and that they are presynaptically located. Neurons located in the substantia gelatinosa are differentially activated by afferent noxious and non-noxiou

• polymyxin sulfate Sensitivity to EphB TKI was also

  2022-06-10

  

  Sensitivity to EphB3 TKI was also demonstrated in a colon cancer cell line, COLO 205, with high expression of EphB3. We found not only exogenous but also endogenous EphB3 protein was expressed in the COLO 205 polymyxin sulfate after transient transfection of pCMV6-AC-GFP/EphB3, and both were demonst

• In summary PPARG and FFAR are

  2022-06-10

  

  In summary, PPARG and FFAR1 are connected in several ways, and the presented interaction is mechanistically reasonable. Additional investigations are required to elucidate the exact details of the underlying physiology. However, our findings are of immanent importance for the treatment of type 2 dia

• The most abundant form of Hat p in the

  2022-06-10

  

  The most abundant form of Hat1p in the nucleus is apt to be in the form of the NuB4 complex [96]. In the context of Quinupristin-Dalfopristin Complex mesylate assembly, the function of the NuB4 complex may be similar to that ascribed for the cytoplasmic HAT1 complex. That is, the NuB4 complex may be

• This crosstalk may be responsible for

  2022-06-10

  

  This crosstalk may be responsible for the beneficial effects of histamine H2 receptor inverse agonists on azilsartan medoxomil pathologies and may also explain unwanted effects of these drugs on other tissues. In this way, Allen et al. reported an anaphylactoid reaction following cessation of high-

15797 records 404/1054 page Previous Next First page 上5页 401402403404405 下5页 Last page