• We previously showed that huntingtin HTT

  2018-10-24

  

  We previously showed that huntingtin (HTT), the protein mutated in Huntington’s disease (HD), is required in murine neuronal progenitors for appropriate spindle orientation and for cell fate determination (Godin et al., 2010). Yet, the mechanisms underlying HTT function during spindle orientation re

• br Results br Discussion The

  2018-10-24

  

  Results Discussion The homing/engraftment of MSCs is the process by which cells migrate, engraft, and exert local functional effects. Homing involves a cascade of events initiated by shear-resistant adhesive interactions between flowing cells and the target endothelium or extracellular matrix.

• br Results br Discussion This work represents a number

  2018-10-24

  

  Results Discussion This work represents a number of important advances for the study of axolotl regeneration. First, we have shown for several genomic loci that TALENs and CRISPRs can induce targeted deletions in a large proportion of cells from injected animals. In all cases, CRISPRs yielded

• Epithelial stem cells in the mammary microenvironment may be

  2018-10-24

  

  Epithelial stem mm stock in the mammary microenvironment may be exposed to abnormally high levels of BMP2 over a prolonged period. Simultaneously, epithelial cells, including stem cells, may accumulate genetic alterations that increase their susceptibility to transforming agents, such as a change in

• br Results br Discussion GRM

  2018-10-24

  

  Results Discussion GRM7 may be associated with Lomustine developmental disorders, including ADHD (Elia et al., 2012) and ASD (Yang and Pan, 2013). However, there is no direct evidence regarding whether or how GRM7 regulates brain development and neurogenesis. Neurogenesis in the developing br

• br Experimental Procedures br Acknowledgments

  2018-10-24

  

  Experimental Procedures Acknowledgments Introduction Hematopoietic stem her2 inhibitor (HSCs) are capable of both self-renewal and production of mature blood lineages. Players in this balanced regulation include transcription factors, cell-cycle regulators, signaling molecules, surface rec

• In this study we further show

  2018-10-24

  

  In this study, we further show that b-hydroxybutyrate of SUV39H1 in HSC is controlled by the highly conserved miR-125 miRNA family. While previously shown to be important regulators of HSC self-renewal and differentiation potential (O\'Connell et al., 2010; Ooi et al., 2010), the contribution of mi

• br Results br Discussion The

  2018-10-24

  

  Results Discussion The length of poly(A) tails plays an important role in controlling mRNA degradation and translational silencing, and is therefore dynamically regulated during development and disease (Eckmann et al., 2011; Norbury, 2013). A recent study showed that poly(A) tail length predom

• br Introduction Hearing loss is the most common congenital s

  2018-10-24

  

  Introduction Hearing loss is the most common congenital sensory deficit (Chan et al., 2010). Approximately 1 child in 1,000 is affected with severe hearing loss at birth or during early childhood, and this is defined as prelingual deafness (Morton, 1991; Petersen and Willems, 2006), with about ha

• Delivery of Cas protein in an

  2018-10-24

  

  Delivery of Cas9 protein in an RNP complex with the sgRNA avoids the need for in vivo transcription and translation. Moreover, this approach yields high expression shortly after nucleofection, followed by rapid degradation, thereby facilitating efficient gene editing while minimizing off-target rate

• In summary we show that calreticulin and TGF

  2018-10-24

  

  In summary, we show that calreticulin and TGF-β signaling intersect downstream of TGF-β receptors I and II. The presence of calreticulin permits TGF-β-mediated inactivation of GSK3β and thus promotes SNAIL2/SLUG-regulated repression of E-cadherin. This condition is sine qua non for the expression an

• Although it remains unclear how

  2018-10-24

  

  Although it remains unclear how aPKCi promotes intermediate neurogenesis in the context of our “MGE” differentiation system, there are several intriguing possibilities. First, the aPKC subgroup contains two isoforms, iota (ι or λ) and zeta (ζ), which have been shown to have numerous, distinct functi

• Nanaomycin A The power consumption of the

  2018-10-24

  

  The power consumption of the RCS in the programming mode is less than 5W and 0.5W in the control mode. Since the control of the EDCLLS network by the RCS is continuous, the problem of reducing the standby power is important. The problem was solved by developing a power supply unit for both RCS and

• Together these findings demonstrate the benefit of

  2018-10-24

  

  Together these findings demonstrate the benefit of simultaneous analysis in elucidating potential pathways between the environment and activity, by ensuring that significant relationships are not obscured by unaccounted for aspects of the environment. However, few studies used interaction or mediati

• For the full sample depression scores were adversely affecte

  2018-10-24

  

  For the full sample, depression scores were adversely affected by being widowed, divorced, or never-married, and by having a union dissolve during the interval. Effects on depression of never having been married operated in different directions for men (positively) and women (negatively), however, a

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