• Although technological improvements in terms of specimen acq

  2018-10-23

  

  Although technological improvements in terms of specimen acquisition and processing have been made, much work remains to be done to ensure the quality of biospecimens and harmonization of tissue collection, processing and storage procedures, attributable largely to the long-standing success of forma

• Time dependent BTL was only associated with prostate

  2018-10-23

  

  Time-dependent BTL was only associated with prostate cancer. However, our analyses stratified by timing of BTL measurement relative to cancer diagnosis found associations between both all incident cancers and prostate cancer, and longer BTL measured ≤4years pre-diagnosis. This suggests (as above) th

• These data do not provide evidence that the MMP

  2018-10-23

  

  These data do not provide evidence that the MMP production from macrophages is directly regulated by CBP/β-catenin and that the produced MMPs are involved in fibrosis resolution in our model. The gating strategy for macrophages in analysis of IHL does not exclude monocytes. Moreover, the mechanism b

• There are few in vitro studies

  2018-10-23

  

  There are few in vitro studies that investigate telomere length with PCBs exposure. Immortalized human skin keratinocytes (HaCats) treated with non-dioxin-like PCB28 and PCB52 for up to 48days demonstrated a significant shortening of mean telomere length from days 18–48 (Senthilkumar et al., 2011).

• Based on these considerations and the presented microbiologi

  2018-10-23

  

  Based on these considerations and the presented microbiological and clinical observations, we decided to stop the PT trial at interim analysis. In summary, while phage therapy is still one very important alternative tool against antibiotic resistance, we need to understand in detail the in vivo inte

• br Materials and Methods br Results br Discussion Understand

  2018-10-23

  

  Materials and Methods Results Discussion Understanding the biology of human DC surface receptors and the functional consequences of the actions of individual receptors is fundamental for the rational design of medicines for cancers, inflammatory diseases (including autoimmune diseases) and

• br Author Contributions br Disclosure br Acknowledgements

  2018-10-23

  

  Author Contributions Disclosure Acknowledgements We are grateful to J. De Rijck for critical reading and thank P. Van de Velde, B. Vanremoortel and NJ. Van der Veeken for their technical assistance. Viral vector production was performed at the Leuven Viral Vector Core. LEDGINs were synthesi

• Non supervised clustering of gene

  2018-10-23

  

  Non-supervised clustering of gene expression divided the ALLs into eight subgroups. It will be interesting to learn if these subgroups overlap with the ones reported by Harvey et al. for an American cohort for pediatric ALLs (). The most significant findings are the discoveries of in-frame fusions o

• Using a wide array of histological and electrophysiological

  2018-10-23

  

  Using a wide array of histological and electrophysiological experimental approaches, these data clearly support a mechanistic role of neuronal ginsenoside rg3 in the intrinsic epileptogenicity of human HH and strenghten the cellular model in which HH neuron clusters of spontaneously firing interneu

• In conclusion our MD simulations of STING CTT and

  2018-10-23

  

  In conclusion, our MD simulations of STING-CTT and experimental verification revealed the dynamics of the CTT involved in ligand binding and phosphorylation. The site-directed mutagenesis studies confirmed the importance of the formation of the local structure in the CTT, and further identified seve

• br Funding Sources This work was supported by the German

  2018-10-23

  

  Funding Sources This work was supported by the German Federal Ministry of Education and Research (BMBF), Grant number 01ER0809 and the German Cancer Research Center (DKFZ Heidelberg, Germany). Biomarker analyses were provided by Epiontis, Berlin. Sven Olek was supported by the German Federal Mini

• Schizophrenia is also characterized by abnormalities in

  2018-10-23

  

  Schizophrenia is also characterized by abnormalities in the cortical circuitry underlying gamma oscillations elicited by a variety of stimuli and tasks (Uhlhaas et al., 2010). Especially, individuals with schizophrenia exhibit deficits in the auditory steady state response (ASSR) induced by gamma fr

• Chronic circadian dysfunction is a significant risk factor f

  2018-10-23

  

  Chronic circadian dysfunction is a significant risk factor for a range of diseases, from sleep disorders to diabetes and cancer (Bass and Takahashi, 2010). A thorough understanding of the mechanisms of circadian dysfunction - a frequent occurrence in the modern lifestyles - is therefore critically i

• In the present study we

  2018-10-23

  

  In the present study, we show that NKCC1 inhibition (in addition to decreasing cell migration) disrupts the regular formation and amount of bundled am630 filaments in human primary derived-GBM cells. In addition, we observed that EGF treatment (which activates NKCC1 phosphorylation and actin bundli

• order AZD1152 br Translating Senolytics into Clinical Treatm

  2018-10-23

  

  Translating Senolytics into Clinical Treatments Healthspan, lifespan, or other very long-term potential endpoints for clinical trials of interventions that target basic aging processes, including SASP-inhibitors or senolytics, would be difficult or next to impossible to study for reasons that are

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