• Creating a genetically diverse set of differentiated

  2018-10-20

  

  Creating a genetically diverse set of differentiated 5-ht3 for the purposes of phenotype-genotype studies would have great value in pharmacogenomics, a field that has relied primarily on EBV-transformed lymphoblastoid cell lines (Moen et al., 2012; Wheeler and Dolan, 2012; Welsh et al., 2009). Tissu

• br Resource table Resource details

  2018-10-20

  

  Resource table: Resource details Expanded T calculate concentration isolated from a 38year-old Japanese healthy male were reprogrammed employing Sendai virus vectors (SeVdp) expressing four reprogramming factors, OCT3/4, SOX2, cMYC, KLF4. SeVdp is integration-free vector, and the absence of rep

• br Materials and methods br Acknowledgments We would like to

  2018-10-20

  

  Materials and methods Acknowledgments We would like to thank Dr. Saran Karumbayaram for providing guidance in the culture and expansion of the primate fibroblasts. We would also like to thank Steven Dowdy for depositing the T7-VEE-OKS-iG plasmid (Addgene). This project was funded by NIH grant

• miR a has been extensively studied

  2018-10-20

  

  miR-29a has been extensively studied in different fields. miR-29a has been reported to be associated with cardiac hypertrophy and fibrosis (Roncarati et al., 2014), and functions as a negative regulator of extracellular matrix remodeling (van Rooij et al., 2008). We have previously reported that miR

• These results with fresh non fractionated

  2018-10-20

  

  These results with fresh, non-fractionated, not culture-expanded, adipose tissue-derived SVF are comparable with other two previously reported clinical series, using cultured adipose-derived ADSCs with controlled cell doses. The adipose tissue contains large populations of mesenchymal caffeic acid p

• Although the present study focuses predominantly on keratino

  2018-10-20

  

  Although the present study focuses predominantly on keratinocytes, it has been known for many years that fibroblasts play an important role in wound healing and in remodeling the extracellular matrix. Thus, an ideal bioengineered graft will always need to incorporate fibroblasts as well as keratinoc

• Further support for the hierarchical two

  2018-10-20

  

  Further support for the hierarchical two-stem-cell model came with the discovery of an additional reserve ISC marker locus, Hopx, encoding an atypical homeodomain protein with functions in early heart development (Chen et al., 2002). An IRES-CreERT2 cassette inserted into the endogenous Hopx locus r

• Cell cycle adaptations in human ESCs

  2018-10-20

  

  Cell-cycle adaptations in human ESCs (hESCs) are less defined. In contrast to mESCs, hESCs exhibit significant fluctuation of cyclin expression in a cell-cycle-dependent manner (Neganova et al., 2009), indicating differences in the regulation of key cell-cycle proteins between the two cell types. Si

• A role for PI K controlling ENPs

  2018-10-20

  

  A role for PI3K controlling ENPs fits well with current ideas of how FGF, BMP, β-catenin, and FAT4 regulate ENP self-renewal and differentiation (Figure 4C). The ENPs all receive the differentiation promoting β-catenin signal from the ureteric bud, but only the TAK-242 that receive a stromal signal

• br Experimental Procedures Extended details outlining specif

  2018-10-20

  

  Experimental Procedures Extended details outlining specific steps and protocols can be found in the Supplemental Experimental Procedures. Author Contributions Acknowledgments Introduction Proximal spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder caused by t

• br Results br Discussion Here we report on different mutant

  2018-10-20

  

  Results Discussion Here we report on 14 different mutant hESC lines, termed DM1 hESCs, that were derived from DM1-affected preimplantation embryos. Previous studies employed DM1 hESCs to explore the causal role of CTG expansion on neurite formation and neuromuscular connections and for charact

• The cycling and quiescence of MaSCs has

  2018-10-20

  

  The cycling and quiescence of MaSCs has been especially difficult to study (Visvader and Stingl, 2014). It has been shown that long-lived, label-retaining cells are enriched in the MaSC/basal compartment, indicating they are slowly dividing (Shackleton et al., 2006). However, it is still unclear how

• Myriocin Previous studies have shown that BM

  2018-10-20

  

  Previous studies have shown that BM-MSCs can be labeled by markers including Prx1, Dermo1, leptin receptor, and Nestin (Mendelson and Frenette, 2014; Morrison and Scadden, 2014). Our lineage-tracing experiments confirm that Prx1+ BM-MSCs can differentiate into osteoblasts, chondrocytes, and adipocyt

• In this issue of E Biomedicine Mehta et

  2018-08-23

  

  In this issue of E-Biomedicine, Mehta et al. () present a phylogeographic study to assess the characteristics of HIV transmission in the Tijuana–San Diego crossing of the Mexico–U.S. border region. This work is a good example of how phylogenetic and phylogeographic analyses on already existing HIV s

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