• DNA microarray is one of the highly discriminatory

  2018-11-06

  

  DNA microarray is one of the highly discriminatory sequence-based molecular approaches that can quickly and accurately identify the relatedness of organisms by presence/absence of domoic acid in the pathogens. Low density microarray, targeting several major virulence genes has previously been propo

• We have utilized an adenovirus Ad vector as

  2018-11-06

  

  We have utilized an adenovirus (Ad) vector as a tool for transduction of functional genes into stem cells, because Ad vectors are relatively easy to construct, can be produced at high titers, and mediate efficient and transient gene expression in both dividing and nondividing cells. We have demonstr

• Guldberg s group Peister et

  2018-11-06

  

  Guldberg\'s group (Peister et al., 2009) demonstrated the potential of AFSCs to produce 3D mineralized bioengineered constructs in vitro and in vivo, suggesting that AFSCs may be an effective cell source for functional repair of large bone defects. In particular, it was shown that: i) in vitro pre-d

• br Materials and methods br Results

  2018-11-06

  

  Materials and methods Results To easily quantify hematopoietic development from human ES cells, we created a fluorescent reporter line. The pan-hematopoietic surface marker, CD43 (leukosialin/SPN), is expressed in all hematopoietic lineages beginning at the hematopoietic progenitor stage durin

• Anti-cancer Compound Library br Introduction Both the excess

  2018-11-06

  

  Introduction Both the excess (obesity) and the lack/atrophy (lipodystrophy) of adipose tissue are associated with altered metabolism and lead to major diseases. In particular, the prevalence of obesity-linked diseases has increased worldwide during the past 10years (Savage et al., 2007). The chro

• In the last couple of years several

  2018-11-06

  

  In the last couple of years several craniofacial NCSC-populations within the head were described. Such BLZ945 were identified e.g. within the dental pulp and the periodontal ligament (Arnold et al., 2010; Waddington et al., 2009; Widera et al., 2007). Importantly, adult stem cells tend to transform

• Inflammatory changes are observed in AD

  2018-11-06

  

  Inflammatory changes are observed in AD brains, particularly at the vicinity of senile plaques. They are abundant in activated microglia, which are the resident macrophages in the central nervous system, in both human AD samples (Mattiace et al., 1990; Perlmutter et al., 1990) and transgenic mouse m

• In contrast to Notch Myb

  2018-11-06

  

  In contrast to Notch Myb activation does not affect cyst-like organoid formation, although MybER increases the percentage of isolated crypts capable of forming an organoid and increases adenoma formation in vivo (Malaterre et al., manuscript submitted). Interesting in this context is that MybER indu

• Despite published evidence that this prevalent view was inco

  2018-11-06

  

  Despite published evidence that this prevalent view was incorrect (Beltrami et al., 2001; Quaini et al., 2002; Urbanek et al., 2003; Urbanek et al., 2005; Anversa et al., 2002; Nadal-Ginard et al., 2003), it took the publication of Bergmann et al., 2009, to produce a significant switch in the preval

• br Results br Discussion In this study we investigated

  2018-11-06

  

  Results Discussion In this study, we investigated the mode of developmental commitment and competence toward the DE and NE lineages in hESCs in response to changes in Nodal/Activin signaling activity. Four days of enhanced Nodal/Activin signaling was sufficient to commit hESCs toward the DE li

• Material and methods br Results Quiescent cells

  2018-11-06

  

  Material and methods Results Quiescent cells can be identified in vivo by virtue of their ability to retain label. Historically, this was achieved by treating animals with nucleotide analogues, for example 5-bromo-2′-deoxyuridine (BrdU) or tritiated thymidine, that are incorporated into DNA duri

• The following are the supplementary data related to

  2018-11-06

  

  The following are the supplementary data related to this article. Acknowledgments This work was supported by the Andrew L. Warshaw, MD Institute for Pancreatic Cancer Research, Massachusetts General Hospital, and by NIH-P01CA117969 to SPT. We would like to Thank Dr. Timothy Wang, Dorothy L. and

• Why the maintenance factors are not essential for normal bla

  2018-11-06

  

  Why the maintenance factors are not essential for normal EAI045 development is unclear. One possibility is that under normal conditions, the inner cell mass is transient, so that even the complete absence of any of these factors does not produce the full detrimental effect. However, if the inner ce

• Progression of maladaptive LV remodeling increased wall stre

  2018-11-06

  

  Progression of maladaptive LV remodeling, increased wall stress and transition to heart failure are associated with an enhanced cardiac production of natriuretic peptides (Hohl et al. 2013; van Veldhuisen et al. 2013). TAC led to a marked five- to twenty-fold increase of myocardial BNP and ANP expre

• Our experiments suggest that Runx may be a

  2018-11-06

  

  Our experiments suggest that Runx1 may be a useful target to manipulate in order to direct the endogenous NSPC proliferative response toward maximal neurogenesis following traumatic Tenofovir Disoproxil manufacturer injury. Runx1 over-expression has been demonstrated to facilitate neuronal differen

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