• There are few in vitro studies

  2018-10-23

  

  There are few in vitro studies that investigate telomere length with PCBs exposure. Immortalized human skin keratinocytes (HaCats) treated with non-dioxin-like PCB28 and PCB52 for up to 48days demonstrated a significant shortening of mean telomere length from days 18–48 (Senthilkumar et al., 2011).

• Based on these considerations and the presented microbiologi

  2018-10-23

  

  Based on these considerations and the presented microbiological and clinical observations, we decided to stop the PT trial at interim analysis. In summary, while phage therapy is still one very important alternative tool against antibiotic resistance, we need to understand in detail the in vivo inte

• br Materials and Methods br Results br Discussion Understand

  2018-10-23

  

  Materials and Methods Results Discussion Understanding the biology of human DC surface receptors and the functional consequences of the actions of individual receptors is fundamental for the rational design of medicines for cancers, inflammatory diseases (including autoimmune diseases) and

• br Author Contributions br Disclosure br Acknowledgements

  2018-10-23

  

  Author Contributions Disclosure Acknowledgements We are grateful to J. De Rijck for critical reading and thank P. Van de Velde, B. Vanremoortel and NJ. Van der Veeken for their technical assistance. Viral vector production was performed at the Leuven Viral Vector Core. LEDGINs were synthesi

• Non supervised clustering of gene

  2018-10-23

  

  Non-supervised clustering of gene expression divided the ALLs into eight subgroups. It will be interesting to learn if these subgroups overlap with the ones reported by Harvey et al. for an American cohort for pediatric ALLs (). The most significant findings are the discoveries of in-frame fusions o

• Using a wide array of histological and electrophysiological

  2018-10-23

  

  Using a wide array of histological and electrophysiological experimental approaches, these data clearly support a mechanistic role of neuronal ginsenoside rg3 in the intrinsic epileptogenicity of human HH and strenghten the cellular model in which HH neuron clusters of spontaneously firing interneu

• In conclusion our MD simulations of STING CTT and

  2018-10-23

  

  In conclusion, our MD simulations of STING-CTT and experimental verification revealed the dynamics of the CTT involved in ligand binding and phosphorylation. The site-directed mutagenesis studies confirmed the importance of the formation of the local structure in the CTT, and further identified seve

• br Funding Sources This work was supported by the German

  2018-10-23

  

  Funding Sources This work was supported by the German Federal Ministry of Education and Research (BMBF), Grant number 01ER0809 and the German Cancer Research Center (DKFZ Heidelberg, Germany). Biomarker analyses were provided by Epiontis, Berlin. Sven Olek was supported by the German Federal Mini

• Schizophrenia is also characterized by abnormalities in

  2018-10-23

  

  Schizophrenia is also characterized by abnormalities in the cortical circuitry underlying gamma oscillations elicited by a variety of stimuli and tasks (Uhlhaas et al., 2010). Especially, individuals with schizophrenia exhibit deficits in the auditory steady state response (ASSR) induced by gamma fr

• Chronic circadian dysfunction is a significant risk factor f

  2018-10-23

  

  Chronic circadian dysfunction is a significant risk factor for a range of diseases, from sleep disorders to diabetes and cancer (Bass and Takahashi, 2010). A thorough understanding of the mechanisms of circadian dysfunction - a frequent occurrence in the modern lifestyles - is therefore critically i

• In the present study we

  2018-10-23

  

  In the present study, we show that NKCC1 inhibition (in addition to decreasing cell migration) disrupts the regular formation and amount of bundled am630 filaments in human primary derived-GBM cells. In addition, we observed that EGF treatment (which activates NKCC1 phosphorylation and actin bundli

• order AZD1152 br Translating Senolytics into Clinical Treatm

  2018-10-23

  

  Translating Senolytics into Clinical Treatments Healthspan, lifespan, or other very long-term potential endpoints for clinical trials of interventions that target basic aging processes, including SASP-inhibitors or senolytics, would be difficult or next to impossible to study for reasons that are

• br Methods The study covered vaccinations

  2018-10-23

  

  Methods The study covered vaccinations and survival of all children born within the Matlab HDSS between 1986 and 1999 and with follow-up to December 31, 2001. The previous study analysed the role of vaccination for child survival between 6weeks and 9months of age when MV is supposed to be given a

• The depleted RNA was fragmented using RNase III in preparati

  2018-10-23

  

  The depleted RNA was fragmented using RNase III in preparation for amplification of the cDNA library, which was produced by reverse transcription from adapters attached to the ends of the RNA molecules, in accordance with the SOLiD™ Total RNA-Seq kit protocol (Life Technologies™, CA). Next, 6% denat

• Proteins from lysenin family were detected by

  2018-10-23

  

  Proteins from lysenin family were detected by Western blotting (WB) in coelomocyte-containing coelomic fluid of 9 adult earthworms, i.e. the 3 specimens (1–3) from the each group of earthworms, Ea, EfM−, EfM+, as described in [1]. The chemiluminescent signals were observed at the molecular weights 3

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