• It is the first time to report the involvement

  2018-11-08

  

  It is the first time to report the involvement of miRNA-30c in enhancing sphere formation and neural differentiation. The relationships of miRNA-30c and osteodifferentiation and adipocyte differentiation have been discussed previously (Gao et al., 2011; Karbiener et al., 2011; Vimalraj and Selvamuru

• In http www apexbt com

  2018-11-08

  

  In this work, we demonstrate that using hESCs provides a novel in vitro spermatogenic model to assess how reproductive toxicants affect human spermatogenesis. Our results show that 2-BP and DBCP induce germ cell death similarly to that observed in men exposed to each toxicant. As predicted based on

• The following are the supplementary

  2018-11-08

  

  The following are the supplementary data related to this article. Acknowledgments Introduction Inflammation, trauma and tumors may all lead to articular cartilage defects. However, the treatment of these defects remains a clinical challenge. Currently, clinical treatments for articular cartil

• The finding that MHC and myogenin expression does not change

  2018-11-08

  

  The finding that MHC and myogenin expression does not change upon ectopic Msx1 expression but decreases drastically upon Msx2 expression is another piece of evidence for the selective role of MSX2 in dedifferentiation. The previous two studies on MSX1 induction in myotubes did not characterize MHC l

• eicosapentaenoic acid br Materials and methods br

  2018-11-08

  

  Materials and methods Results Discussion It is known that mutation types of SOD1 affect not only enzymatic activity and protein half-life of SOD1, but also age at onset and the survival time of SOD1-ALS patients (Hayward et al., 2002) (Borchelt et al., 1994) (Regal et al., 2006). However, t

• As indicated above EMT MET

  2018-11-08

  

  As indicated above, EMT/MET play a key role in cellular (de-)differentiation. Loss of OCT4 seems to directly contribute to MET induction in various colorectal cancer lines as shown by knockdown of OCT4: This resulted in characteristic changes in cell morphology and reduced pgc-1α inhibitor of EMT m

• br Experimental Procedures br Author Contributions br Acknow

  2018-11-08

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Intestinal crypts contain stem cells and their transit-amplifying (TA) daughter cells. Cells exiting the proliferative crypts onto the villi terminally differentiate into enterocytes, goblet cells, and enteroendocr

• Proper functioning of the RPE is important for maintaining t

  2018-11-08

  

  Proper functioning of the RPE is important for maintaining the health and integrity of the outer retina, photoreceptors, and choriocapillaris. Healthy RPE cells play many crucial roles in the retina, including transportation of nutrients such as glucose or vitamin A from blood to the photoreceptors,

• A recently developed gene editing technology using RNA guide

  2018-11-08

  

  A recently developed gene-editing technology using RNA-guided endonuclease (Gaj et al., 2013), which allows the desired gene to be inserted into a genomic safe harbor (GSH) area (Papapetrou et al., 2011), should be considered to avoid undesirable random genomic insertion of EOS-C(3+)-KR in the gener

• Multiple factors through binding to GPCRs

  2018-11-08

  

  Multiple factors, through binding to GPCRs, orchestrate the regulation of cAMP levels in a cell- and context-dependent manner, an effect that is most likely to be preserved during embryonic hematopoietic emergence and development (Diaz et al., 2015; Goessling et al., 2011; Hoggatt et al., 2009; Jing

• endothelin receptor In many studies the reprogramming factor

  2018-11-08

  

  In many studies, the reprogramming factors were delivered individually using monocistronic vectors. However, due to differences in vector uptake, expression levels of each gene in each cell are highly variable (Lo et al., 2015). Since the ratio between the factors is one of most critical factors for

• Naumann et al reported that

  2018-11-07

  

  Naumann et al. (2010) reported that the absolute number of BrdU+ cells at 4 weeks after the last BrdU injection was similar between hAPP-I5 and control mice, which is inconsistent with our results. One possibility for this discrepancy might be the age of mice used in the studies. Six-week-old mice w

• Only a handful of studies examined the RD

  2018-11-07

  

  Only a handful of studies examined the RD-health association outside the U.S. and Europe; all revealed strong evidence that, above and beyond absolute income, RD is an important predictor. In research using a large probability sample of Japanese men and women, RD measured by the Yitzhaki Index was f

• On the other hand hypothesis H postulates

  2018-11-07

  

  On the other hand, HZ-1157 H6 postulates that the influence of the perceived empathy of the leader on trust will be: (a) greater when the leader exercises more a transactional a leadership style or (b) less when the leader employs a more transformational style. In light of the results, one can obse

• br Materials and methods br Results

  2018-11-07

  

  Materials and methods Results and discussion Concluding remarks The compositions and properties of three subtropical soils sampled from respective active disposal sites around the City of Johannesburg (CoJ) were studied together with the chemical alterations that occurred when percolated wi

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